ESP Tipcast 86 Addendum: Meldonium Mayhem

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Meldonium

 

Schematic of mechanisms of action for meldonium. It appears that the reduction of L-carnitene leads to greater reliance on glucose by the heart, improving overall heart function. Other effects include increased release of nitric oxide, which increases local blood flow, and improved CNS function. (from Dombrova 2016)

Schematic of mechanisms of action for meldonium. It appears that the reduction of L-carnitene leads to greater reliance on glucose by the heart, improving overall heart function. Other effects include increased release of nitric oxide, which increases local blood flow, and improved CNS function. (from Dombrova 2016)

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References

Dombrova et al. (2016) Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmocological Research. In press.

Seppälä. (2016) FINADA – Meldonium, or mildronate.

Sjaste et al. (2005) Mildronate: an antiischemic drug for neurological indications. CNS Drug Review. 11(2):151-68.

Stuart et al. (2016) Meldonium use by athletes at the Baku 2015 European Games. Adding data to Ms Maria Sharapova’s failed drug test case.  BMJ Blogs.

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